Product Name: GluR2 (200-208) / HIV1 Tat (47-57) Dansyl
Product Number: PE-07AAB95
Size: 200 µg      Price:87.00
1 mg      $US174.00
5 mg      381.00
Peptide Name: GluR2 (200-208) / HIV1 Tat (47-57) Dansyl

Product Use: Peptide stimulates the cytolytic and proliferative activity of NK cells at concentrations equivalent to full-length HSP70 protein.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Human immunodeficiency virus 1

Peptide Sequence: YGRKKRRQRRRYKEGYNVYG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: Lys(Dansyl)

Peptide Molecular Mass Calculated: 2910.3 Da

Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: GLuR2 is a receptor for the excitatory neurotransmitter L-glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. Binding of L-glutamate induces a conformation change, leading to the opening of the cation channel, and to generate an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
References

[1] Dalton GL, Wang YT, Floresco SB, Phillips AG. Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear. Neuropsychopharm. 2008 Sep;33(10):2416-26. Epub 2007 Nov 28. PMID: 18046303.

[2] Kim J, Lee S, Park K, Hong I, Song B, Son G, Park H, Kim WR, Park E, Choe HK, Kim H, Lee C, Sun W, Kim K, Shin KS, Choi S. Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20955-60. Epub 2007 Dec 26. PMID 18165656.