Product Name: Urotensin-2 (114-124) acid
Product Number: PE-05AAA80
| Size: | 1 mg | Price: | 77.00 | |
| 5 mg | $US | 150.00 | ||
| 20 mg | 322.00 |
Peptide Name: Urotensin-2 (114-124) acid
Product Use: Urotensin-2 is a highly potent vasoconstrictor that has been identified as a ligand for the orphan receptor GPR14 , which elicits potent vasoconstriction in primates.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ETPDCFWKYCV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Modifications Other: C-C cyclized
Peptide Molecular Mass Calculated: 1390.4 Da
Product Use: Urotensin-2 is a highly potent vasoconstrictor that has been identified as a ligand for the orphan receptor GPR14 , which elicits potent vasoconstriction in primates.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ETPDCFWKYCV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Modifications Other: C-C cyclized
Peptide Molecular Mass Calculated: 1390.4 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: Intracerebroventricular urotensin II administration produces pressor and tachycardic responses. U-II is localized to the medulla oblongata of the brain and the spinal cord in the central nervous system, but is also found in adrenal glands, kidney and spleen, suggesting neurohormonal or hormonal properties.
References
[1] Zheng J, Pinkston JD, Zoutendam PH, Taylor LT. Feasibility of supercritical fluid chromatography/mass spectrometry of polypeptides with up to 40-mers. Anal Chem. 2006 Mar 1;78(5):1535-45. PMID: 16503605.
[2] Bennett RT, Jones RD, Morice AH, Smith CF, Cowen ME. Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries. Thorax. 2004 May;59(5):401-7. PMID: 15115867.
[3] Coulouarn Y, Jégou S, Tostivint H, Vaudry H, Lihrmann I. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett. 1999 Aug 20;457(1):28-32. PMID: 10486557.
[1] Zheng J, Pinkston JD, Zoutendam PH, Taylor LT. Feasibility of supercritical fluid chromatography/mass spectrometry of polypeptides with up to 40-mers. Anal Chem. 2006 Mar 1;78(5):1535-45. PMID: 16503605.
[2] Bennett RT, Jones RD, Morice AH, Smith CF, Cowen ME. Vasoconstrictive effects of endothelin-1, endothelin-3, and urotensin II in isolated perfused human lungs and isolated human pulmonary arteries. Thorax. 2004 May;59(5):401-7. PMID: 15115867.
[3] Coulouarn Y, Jégou S, Tostivint H, Vaudry H, Lihrmann I. Cloning, sequence analysis and tissue distribution of the mouse and rat urotensin II precursors. FEBS Lett. 1999 Aug 20;457(1):28-32. PMID: 10486557.
[4] Boucard AA, Sauvé SS, Guillemette G, Escher E, Leduc R. Photolabelling the rat urotensin II/GPR14 receptor identifies a ligand-binding site in the fourth transmembrane domain. Biochem J. 2003 Mar 15;370(Pt 3):829-38. PMID: 12495432.
[5] Coulouarn Y, Lihrmann I, Jegou S, Anouar Y, Tostivint H, Beauvillain JC, Conlon JM, Bern HA, Vaudry H. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15803-8. PMID: 9861051.
[5] Coulouarn Y, Lihrmann I, Jegou S, Anouar Y, Tostivint H, Beauvillain JC, Conlon JM, Bern HA, Vaudry H. Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15803-8. PMID: 9861051.
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