Product Name: CK2pSelectide
Product Number: PE-04AXK75
| Size: | 200 µg | Price: | 14.00 | |
| 1 mg | $US | 27.00 |
Peptide Name: CK2pSelectide
Product Use: For assaying the phosphotransferase activity of Casein protein-serine kinase 2 alpha/ alpha prime (UniProt ID P19784).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEIEDSDD-pS-EEGC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1790.64 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Product Use: For assaying the phosphotransferase activity of Casein protein-serine kinase 2 alpha/ alpha prime (UniProt ID P19784).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEIEDSDD-pS-EEGC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1790.64 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: CK2p
Storage Conditions: -20°C
Peptide Recommended Enzyme: CK2p
Scientific Background: CK2a1 (CSNK2A1) is a protein-serine/threonine kinase of the Other group and CK2 family. CK2a1 is activated by the CK2-beta regulatory subunit and also by binding p38a MAPK. CK2 is potently inhibited by heparin. It is involved in various cellular processes, such as cell cycle control, apoptosis, transcription, and viral infection. It can phosphorylate human p53 protein a tS392 with presence of UV irradiation, which may be a potential mechanism for p53 activation by UV irradiation. It also phosphorylates the caspases CASP9 and CASP2, and hence negatively regulates apoptosis. CK2a1 levels are often up-regulated by 2-fold in expression in many human tumours.
© Kinexus Bioinformatics Corporation 2017