Product Name: HGK (178-190) pT181+pT187
Product Number: PE-04AXI99
| Size: | 200 µg | Price: | 40.00 | |
| 1 mg | $US | 81.00 |
Peptide Name: HGK (178-190) pT181+pT187
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T181 and T187 phosphorylation predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (LDR-pT-VGRRN-pT-FIG-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The presentation as a dimer increases the potential activity. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T181 and T187 phosphorylation predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: (LDR-pT-VGRRN-pT-FIG-βA-Cys)2
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated, dimer
Peptide Molecular Mass Calculated: 3757.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: stable
Peptide Molecular Mass Calculated: 3757.8 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: stable
Scientific Background: ZC1 (HGK, MAP4K4) is a protein-serine/threonine kinase of the STE group and STE20 family. It may play a role in the response to environmental stress and cytokines such as TNF-alpha, and appears to act upstream of the JUN N-terminal pathway. ZC1 can phosphorylate SMAD1 at T322. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
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