Product Name: Tyk2 (1051-1066) pY1054+pY1055+pS1063
Product Number: PE-04AXH80
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Peptide Name: Tyk2 (1051-1066) pY1054+pY1055+pS1063
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y1054 and Y1055 phosphorylation stimulate phosphotransferase activity. Effect of phosphorylation of S1063 is unknown.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHE-pY-pY-RVREDGD-pS-PVF
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y1054 and Y1055 phosphorylation stimulate phosphotransferase activity. Effect of phosphorylation of S1063 is unknown.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHE-pY-pY-RVREDGD-pS-PVF
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2381.2 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Stable as powder; solution tends to dimerize
Peptide Molecular Mass Calculated: 2381.2 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Stable as powder; solution tends to dimerize
Scientific Background: Tyk2 is a protein-tyrosine kinase of the TK group and JakA family. Phosphorylation of Y1054 and Y1055 increases phosphotransferase activity. Tyk2 mediates intracellular signal transduction from Type I interferon-alpha/beta receptor (IFN) signalling and phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumours.
© Kinexus Bioinformatics Corporation 2017