Product Name: TBK1 (169-182) pS172+pT176+pY179
Product Number: PE-04AXG90
| Size: | 200 µg | Price: | 24.00 | |
| 1 mg | $US | 47.00 |
Peptide Name: TBK1 (169-182) pS172+pT176+pY179
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S172 phosphorylation stimulates phosphotransferase activity. T176 and Y179 phosphorylation are predicted to inhibit phosphotransferase actviity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QFV-pS-LYG-pT-EE-pY-LHP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S172 phosphorylation stimulates phosphotransferase activity. T176 and Y179 phosphorylation are predicted to inhibit phosphotransferase actviity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: QFV-pS-LYG-pT-EE-pY-LHP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2138.03 Da
Peptide Purity Percent after Synthesis and Purification: <50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Peptide Molecular Mass Calculated: 2138.03 Da
Peptide Purity Percent after Synthesis and Purification: <50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Scientific Background: TBK1 (NAK) is a protein-serine/threonine kinase of the Other group and IKK family. It plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. To establish such an antiviral state. It mediates the immune response via signalling with TANK, TRAF3, IRF3, IRF7, and DDX3X. It can act as a scaffold for the proteins FADD, AZI2, MAVS, TRADD, TANK or TBKBP1/SINTBAD. TBK1 can be ubiquitinated at K30 and K401. TBK1 is phosphorylated and activated at S172A, Y325, and Y577. It can phosphorylate NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. It phosphorylates and activates AKT1.
© Kinexus Bioinformatics Corporation 2017