Product Name: PRPF4B (844-858) pT847+pY849+pS852+pY855
Product Number: PE-04AXC75
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Peptide Name: PRPF4B (844-858) pT847+pY849+pS852+pY855
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T847 and Y849 phosphorylation stimulate phosphotransferase activity. S852 and Y855 phosphorylation are predicted to be inhibitory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NDI-pT-P-pY-LV-pS-RF-pY-RAP
Peptide Modifications N Terminus: Free amino
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. T847 and Y849 phosphorylation stimulate phosphotransferase activity. S852 and Y855 phosphorylation are predicted to be inhibitory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NDI-pT-P-pY-LV-pS-RF-pY-RAP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2347.2 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 2347.2 Da
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: Not stable
Scientific Background: PRPF4B (PRP4) is a protein-serine/threonine kinase of the CMGC group and DYRK family. It is known to regulate pre-mRNA splicing. Identified substrates for PRPF4B include splicing factors SF2, PRPF6, and PRPF31 as well as the KLF13 and Elk1 transcription factors. The enzymatic activity of PRP4 is required for viability of pancreatic, colon and large B-cell lymphoma cancer cell lines (PubMed: 24003220). Inhibition of PRP4 activity by shRNAs was shown to resensitize chemoresistant human ovarian and breast cancer to paclitaxel treatment.
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