Product Name: HPK1 (162-174) pT165+pS171
Product Number: PE-04AUV99
| Size: | 200 µg | Price: | 50.00 | |
| 1 mg | $US | 101.00 |
Peptide Name: HPK1 (162-174) pT165+pS171
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. These are the major in vivo phosphorylation sites in HIPK1. T165 and S171 phosphorylation stimulate phosphotransferase activity. Phosphorylation regulates transcription.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: IGA-pT-LARRL-pS-FIG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. These are the major in vivo phosphorylation sites in HIPK1. T165 and S171 phosphorylation stimulate phosphotransferase activity. Phosphorylation regulates transcription.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: IGA-pT-LARRL-pS-FIG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1750.2 Da
Peptide Purity Percent after Synthesis and Purification: >70
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: stable, tends slightly to dimerize
Peptide Molecular Mass Calculated: 1750.2 Da
Peptide Purity Percent after Synthesis and Purification: >70
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: stable, tends slightly to dimerize
Scientific Background: HPK1 (MAP4K1) is a protein-serine/threonine kinase in the STE group, STE20 family and KHS subfamily, which plays a role in the response to environmental stress. It appears to act upstream of the Jun N-terminal pathway. It may play a role in hematopoietic lineage decisions and growth regulation. It undergoes autophosphorylate.
© Kinexus Bioinformatics Corporation 2017