Product Name: EphA3 (775-785) pY779+pT780+pT781
Product Number: PE-04ATH99
| Size: | 200 µg | Price: | 59.00 | |
| 1 mg | $US | 119.00 | ||
| 5 mg | 267.00 |
Peptide Name: EphA3 (775-785) pY779+pT780+pT781
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y779 and probbaly T780 and T781 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: PEAA-pY-pT-pT-RGGK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y779 and probbaly T780 and T781 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: PEAA-pY-pT-pT-RGGK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1563.6 Da
Peptide Purity Percent after Synthesis and Purification: >70
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: solutions forms dimers
Peptide Molecular Mass Calculated: 1563.6 Da
Peptide Purity Percent after Synthesis and Purification: >70
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Storage Stability: solutions forms dimers
Scientific Background: EphA3 is a protein-tyrosine kinase of the TK group and Eph family. It is a receptor kinase that binds ephrin ligands to induce contact signalling. It is activated by binding ephrin-A1, A2, A3, A4 or A5. Phosphorylation of Y596, Y602 and Y779 increases phosphotransferase activity and interaction with Crk. Upregulation of EphA3 is common in lung cancer and melanomas. Its mutation pattern in human tumours is very characteristic of a tumour suppressor protein.This pathway can regulate cell adhesion, migration, and movement. EphA3 function is inhibited and EFNA5 binding interrupted with the V133E, and F152L mutations. EphA3 is linked to Pleomorphic Rhabdomyosarcoma, which is a rare disease which is related to colorectal cancer, and can also affect the uterus, heart, and skeletal muscle tissues.
© Kinexus Bioinformatics Corporation 2017