Product Name: DDR1 (793-800) pY796+pY797
Product Number: PE-04ASZ01
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Peptide Name: DDR1 (793-800) pY796+pY797
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y796 and Y797 phosphorylation stimulate phosphotransferase activity and Y796 phosphorylation induces interaction with SHP2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AGD(pY)(pY)RVQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y796 and Y797 phosphorylation stimulate phosphotransferase activity and Y796 phosphorylation induces interaction with SHP2.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AGD(pY)(pY)RVQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Storage Conditions: -20°C
Scientific Background: DDR1 is a protein-tyrosine kinase of the TK group and DDR family an an adhesion protein. It is a cell surface receptor for fibrillar collagen and regulates cell attachment, cell migration, differentiation, and cell proliferation. It undergoes autophosphorylation in response to fibrillar collagen binding. Phosphorylation at Y396, Y703 and Y796 induces interaction with SHP2 and Y513 to Shc1. It is mainly expressed by epithelial cells in the kidneys, lungs, gastrointestinal tract, and brain, and may be activated by various types of collagen including types I, II, III, and V. DDR1 can interact with Notch1 and produce a prosurvival effect. It can also enhance cancer cell migration. DDR1 may be an oncoprotein (OP) or a tumour suppressor protein (TSP). DDR1 has been shown to be significantly overexpressed in some human tumours. It has been shown to promote the proliferation of neoplastic cells. Multiple sites of mutation lead to either inhibition or constitutively activation of this receptor. The gene expression was found to be upregulated by p53 in human osteosarcoma cells.
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