Product Name: Jun (59-67) pS63
Product Number: PE-04ARC85
| Size: | 200 µg | Price: | 34.00 | |
| 1 mg | $US | 67.00 |
Peptide Name: Jun (59-67) pS63
Product Use: Services as a blocking peptide for use with the Jun-pS63 rabbit polyclonal antibody (Cat. No.: AB-PN557) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the N-terminus of the transcription factor. These are the major in vivo sites of phosphorylation of c-Jun. Phosphorylation increases transcriptional activity
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DLLT-pS-PDV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Gly-Cys
Product Use: Services as a blocking peptide for use with the Jun-pS63 rabbit polyclonal antibody (Cat. No.: AB-PN557) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the N-terminus of the transcription factor. These are the major in vivo sites of phosphorylation of c-Jun. Phosphorylation increases transcriptional activity
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DLLT-pS-PDV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Gly-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1098.13 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Jun - pS63 phosphosite-specific antibody (Cat. No.: AB-PN557)
Peptide Molecular Mass Calculated: 1098.13 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Jun - pS63 phosphosite-specific antibody (Cat. No.: AB-PN557)
Scientific Background: c-Jun is a ranscription factor in the AP1 complex that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3, which leads to increased steroidogenic gene expression upon cAMP signalling pathway stimulation. It is involved in activated KRas-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells.
© Kinexus Bioinformatics Corporation 2017