Product Name: TTK (674-680) pT676
Product Number: PE-04AQF99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: TTK (674-680) pT676
Product Use: Services as a blocking peptide for use with the TTK-pT676 rabbit polyclonal antibody (Cat. No.: AB-PK842) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T676 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DTT-pS-VVK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the TTK-pT676 rabbit polyclonal antibody (Cat. No.: AB-PK842) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T676 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DTT-pS-VVK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1002.01 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TTK - pT676 phosphosite-specific antibody (Cat. No.: AB-PK842)
Peptide Molecular Mass Calculated: 1002.01 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TTK - pT676 phosphosite-specific antibody (Cat. No.: AB-PK842)
Scientific Background: TTK (ESK) is a protein-serine/threonine kinase of the Other group and TTK family. It is a dual specificity protein kinase that can phosphorylate serine, threonine, and tyrosine residues and has a role in cell cycle progression through regulating centrosome duplication during S-phase. This function was CDK2-mediated by direct activation of TTK.. Through CDCA8 phosphorylation TTK can modulate AurKB at the centromere to align the chromosomes. Phosphorylation of S582, T675, T676, T686, and S742 increases phosphotransferase activity. Phosphorylation of T806 inhibits phosphotransferase activity. TTK is a dual-specificity protein kinase with activity toward serine, threonine and tyrosine residues. TTK was found to have a role Overexpression or dysregulation of TTK activtiy may promote cancer through aberrant duplication of centrosomes and promotiong of aneuploidy. Mutations in TTK are highly correlated in the development of microsatellite-unstable colorectal cancers. TTK is linked to pancreatic ductal adenocarcinoma (PDAC), and important in the growth and proliferation of PDAC cancer cells. Triple Negative Breast Cancer (TNBC) is a highly aggressive form of cancer and TTK is consistently upregulated in TNBC tissues.
© Kinexus Bioinformatics Corporation 2017