Product Name: TIF1g (1116-1122) pS1119
Product Number: PE-04AQB95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: TIF1g (1116-1122) pS1119
Product Use: Services as a blocking peptide for use with the TRIM33-pS1119 rabbit polyclonal antibody (Cat. No.: AB-PK836) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of kinase. The effect of its phosphorylation is unclear. This is a major site of phosphorylation for TRIM33.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RLK-pS-DER
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the TRIM33-pS1119 rabbit polyclonal antibody (Cat. No.: AB-PK836) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of kinase. The effect of its phosphorylation is unclear. This is a major site of phosphorylation for TRIM33.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RLK-pS-DER
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1156.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TIF1g - pS1119 phosphosite-specific antibody (Cat. No.: AB-PK836)
Peptide Molecular Mass Calculated: 1156.2 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: TIF1g - pS1119 phosphosite-specific antibody (Cat. No.: AB-PK836)
Scientific Background: TRIM33 (TIF1g) is a protein-serine/threonine kinase of the Atypical group and TIF1 family. It functions as an E3 ubiquitin-protein ligase to promote SMAD4 ubiquination, nuclear exclusion, and degradation via the ubiquitin proteasome pathway. In particular, the TRIM33 protein inhibits the SMAD4 transcriptional responses to the TGF-beta/BMP signalling cascade, a key transducer of mitogenic signals. This is accomplished through the ubiquination and subsequent degradation of SMAD4, which prevents the formation of a transcription factor complex between SMAD4, SMAD2, and SMAD3. Therefore, TRIM33 plays a critical role in the regulation of cell proliferation as it influences cellular responsiveness to TGF-beta/BMP signalling. In addition, a protein complex consisting of the TRIM33, SMAD2, and SMAD3 proteins promotes the erythroid differentiation of hematopoietic stem/progenitor cells. It is predicted that the TRIM33-SMAD2/3 and SMAD4-SMAD2/3 protein complexes function as complementary effectors in the regulation of hematopoietic cell fate as mediated by the TGF-beta signalling pathway. TRIM33 appears to be an oncoprotein (OP) and a tumour suppressor protein (TSP). Several gain-of-function mutations affecting the TRIM33 gene have been observed in cancer patients, many involving chromosomal rearrangements with the TRIM33 gene.
© Kinexus Bioinformatics Corporation 2017