Product Name: ROCK1 (910-916) pY913
Product Number: PE-04APL99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: ROCK1 (910-916) pY913
Product Use: Services as a blocking peptide for use with the ROCK1-pY913 rabbit polyclonal antibody (Cat. No.: AB-PK798) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located just before Rho-Binding domain. This is the major in vivo phosphorylation site in ROCK1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EEQ-pY-FEL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the ROCK1-pY913 rabbit polyclonal antibody (Cat. No.: AB-PK798) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located just before Rho-Binding domain. This is the major in vivo phosphorylation site in ROCK1. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: EEQ-pY-FEL
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1210.19 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ROCK1 - pY913 phosphosite-specific antibody (Cat. No.: AB-PK798)
Peptide Molecular Mass Calculated: 1210.19 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: ROCK1 - pY913 phosphosite-specific antibody (Cat. No.: AB-PK798)
Scientific Background: ROCK1 (ROK-beta) is a protein-serine/threonine kinase of the AGC group and DMPK family. It is a key regulator of actin cytoskeleton and cell polarity. It is activated by binding the small G protein RhoA. D1113A substitution leads to abolished cleavage by caspase-3. Down-regulating ROCK1 may be useful strategy for inhibiting migration and invasion of glioma and gastric cancer.
© Kinexus Bioinformatics Corporation 2017