Product Name: MEK5 (308-314) pS311
Product Number: PE-04ANV99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: MEK5 (308-314) pS311
Product Use: Services as a blocking peptide for use with the MEK5-pS311 rabbit polyclonal antibody (Cat. No.: AB-PK699) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S311 phosphorylation stimulates phosphotransferase activity and inhibits interaction with ERK5.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: LVN-pS-IAK
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the MEK5-pS311 rabbit polyclonal antibody (Cat. No.: AB-PK699) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S311 phosphorylation stimulates phosphotransferase activity and inhibits interaction with ERK5.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: LVN-pS-IAK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 997.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MEK5 - pS311 phosphosite-specific antibody (Cat. No.: AB-PK699)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 997.1 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MEK5 - pS311 phosphosite-specific antibody (Cat. No.: AB-PK699)
Scientific Background: MEK5 (MAP2K5) is a Dual specificity protein kinase of the STE group and STE7 family. It is activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis by acting as a scaffold protein for the construction of a complex consisting of MAP3K2 or MAP3K3 and MAP3K5 and MAPK7.
© Kinexus Bioinformatics Corporation 2017