Product Name: MAPKAPK3 (73-79) pY76
Product Number: PE-04ANP99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: MAPKAPK3 (73-79) pY76
Product Use: Services as a blocking peptide for use with the MAPKAPK3-pY76 rabbit polyclonal antibody (Cat. No.: AB-PK692) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain in subdomain II. This is the major in vivo site of phosphorylation of MAPKAPK3. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KLL-pY-DSP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the MAPKAPK3-pY76 rabbit polyclonal antibody (Cat. No.: AB-PK692) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain in subdomain II. This is the major in vivo site of phosphorylation of MAPKAPK3. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KLL-pY-DSP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1088.16 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MAPKAPK3 - pY76 phosphosite-specific antibody (Cat. No.: AB-PK692)
Peptide Molecular Mass Calculated: 1088.16 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MAPKAPK3 - pY76 phosphosite-specific antibody (Cat. No.: AB-PK692)
Scientific Background: MAPKAPK3 is one of several protein kinases that can phosphorylate KinSub1RRDSF. Human MAPKAPK3 is a protein-serine/threonine kinase of 382 amino acid length, with a predicted molecular mass of 42,987 Da. It is a member of the CAMK group of protein kinases in the MAPKAPK family, and MAPKAPK subfamily. This kinase is highly expressed and widely distributed in most tested human tissues. Orthologues of MAPKAPK3 are highly conserved in vertebrates and insects. MAPKAPK3 interacts with TCF3 and with polycomb proteins, such as PCH2 and BMI1/PCGF4. MAPKAPK3 is closely related to MAPKAPK2 sharing 72% nucleotide and 75% amino acid identity (1). MAPKAPK3 is activated by growth inducers and stress stimulation of cells. In vitro studies have demonstrated that ERK1/2, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which indicated the role of MAPKAPK3 as an integrative element of signalling in both mitogen and stress responses (2). MAPKAPK3 has been linked with the development of glioblastoma multiforme (GM).
© Kinexus Bioinformatics Corporation 2017