Product Name: LOK (949-955) pT952
Product Number: PE-04ANM95
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: LOK (949-955) pT952
Product Use: Services as a blocking peptide for use with the LOK-pT952 rabbit polyclonal antibody (Cat. No.: AB-PK686) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of the kinase. This is the major in vivo site of phosphorylation in LOK. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NPS-pT-PSK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the LOK-pT952 rabbit polyclonal antibody (Cat. No.: AB-PK686) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of the kinase. This is the major in vivo site of phosphorylation in LOK. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: NPS-pT-PSK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 982.99 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: LOK - pT952 phosphosite-specific antibody (Cat. No.: AB-PK686)
Peptide Molecular Mass Calculated: 982.99 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: LOK - pT952 phosphosite-specific antibody (Cat. No.: AB-PK686)
Scientific Background: LOK (STK10) is a protein-serine/threonine kinase of the STE group and STE20 family. It can control lymphocyte migration via its phosphotransferase activity. LOK has been shown to phosphorylate MSN and has been implicated in phosphorylating Plk1. LOK can negatively regulate MEKK1/MAP3K1, and may also mediate cell cycle progression. A K65I mutation in LOK seen with Testicular germ cell tumour (TGCT) can induce loss of kinase phosphotransferase activity.
© Kinexus Bioinformatics Corporation 2017