Product Name: Ksr2 (487-493) pS490
Product Number: PE-04ANF95
| Size: | 200 µg | Price: | 37.00 | |
| 1 mg | $US | 74.00 | ||
| 5 mg | 174.00 |
Peptide Name: Ksr2 (487-493) pS490
Product Use: Services as a blocking peptide for use with the Ksr2-pS490 rabbit polyclonal antibody (Cat. No.: AB-PK676) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the KSR1-SAM and kinase catalytic domains. This is the major in vivo phosphorylation site in Krs2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: PRY-pS-DLH
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the Ksr2-pS490 rabbit polyclonal antibody (Cat. No.: AB-PK676) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the KSR1-SAM and kinase catalytic domains. This is the major in vivo phosphorylation site in Krs2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: PRY-pS-DLH
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1140.16 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Ksr2 - pS490 phosphosite-specific antibody (Cat. No.: AB-PK676)
Peptide Molecular Mass Calculated: 1140.16 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Ksr2 - pS490 phosphosite-specific antibody (Cat. No.: AB-PK676)
Scientific Background: Ksr2 (kinase suppressor of Ras 2) is a protein-serine/threonine kinase that functions as a scaffold protein that functionally connects MEK and Raf. The Ksr2 protein has very low kinase catalytic activity, but it can phosphorylate MAP2K1 in vitro with low efficiency at several serine and threonine residues. Ksr2 functions to inhibit MAP3K3-mediated activation of ERK, JNK, and NF-kappa-B signalling pathways, thus blocking MAP3K-medaited production of interleukin-8 (IL-8). In addition, Ksr2 interacts with AMPK (the cellular energy sensor) to maintain energy homeostasis and glucose utilization.
© Kinexus Bioinformatics Corporation 2017