Product Name: EphB2 (777-783) pY780
Product Number: PE-04ALZ95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: EphB2 (777-783) pY780
Product Use: Services as a blocking peptide for use with the EphB2-pY780 rabbit polyclonal antibody (Cat. No.: AB-PK610) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. This is the major in vivo phosphorylation site in EphA2. Y780 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DPT-pY-TSA
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the EphB2-pY780 rabbit polyclonal antibody (Cat. No.: AB-PK610) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. This is the major in vivo phosphorylation site in EphA2. Y780 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DPT-pY-TSA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1007 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: EphB2 - pY780 phosphosite-specific antibody (Cat. No.: AB-PK610)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1007 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: EphB2 - pY780 phosphosite-specific antibody (Cat. No.: AB-PK610)
Scientific Background: EphB2 is a protein-tyrosine kinase of the TK group and Eph family. It is a receptor kinase, and is activated by binding ephrin-B1, B2, or B3. Eph and Eph receptors are associated with nervous system development events, and lead to contact-dependent signalling through adjacent cells. Eph receptors are widely expressed in early development and rarely detected in adult tissues. EphB2 signalling has an important role in the development and structural organization of neurons. EphB2 is also involved in angiogenesis, palate development and inner ear development through endolymph production. EphB2 appears to be a tumour suppressor protein (TSP). The active form of the protein kinase normally acts to inhibit tumour cell proliferation. EphB2 mutations have been found in prostate cancer. Most prostate cancers are adenocarcinomas that derived from acini of the prostatic ducts. K1019X mutation was significantly more common in African American probands. Over-expression of EphB2 has been frequently detected in both well-differentiated adenocarcinomas (10 of 13) and poorly differentiated adenocarcinomas (9 of 14). EphB2 expression restricts the invasiveness of colorectal cancer cells into ephrin-B1 expressing cell populations, thus segregating cancer cells from normal cells.
© Kinexus Bioinformatics Corporation 2017