Product Name: EphB1 (591-597) pY594
Product Number: PE-04ALY90
| Size: | 200 µg | Price: | 41.00 | |
| 1 mg | $US | 82.00 | ||
| 5 mg | 194.00 |
Peptide Name: EphB1 (591-597) pY594
Product Use: Services as a blocking peptide for use with the EphB1-pY594 rabbit polyclonal antibody (Cat. No.: AB-PK609) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the transmembrane domain and the kinase catalytic domain. One of the two major in vivo phosphorylation sites in EphB1. Phosphorylation induces binding to Nck1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MKI-pY-IDP
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the EphB1-pY594 rabbit polyclonal antibody (Cat. No.: AB-PK609) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the transmembrane domain and the kinase catalytic domain. One of the two major in vivo phosphorylation sites in EphB1. Phosphorylation induces binding to Nck1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MKI-pY-IDP
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1132.3 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: EphB1 - pY594 phosphosite-specific antibody (Cat. No.: AB-PK609)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1132.3 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: EphB1 - pY594 phosphosite-specific antibody (Cat. No.: AB-PK609)
Scientific Background: EphB1 is a protein-tyrosine kinase of the TK group and Eph family. It is a receptor kinase that mediates cell contact signalling via binding Ephrin B family (EFNB1, EFNB2 and EFNB3) of ligands. Phosphorylation at Y594 induces interaction with Nck1 and the SH2 domain of Grb10. Phosphorylation at Y928 induces interaction with Grb2 and Grb7. Interaction with Shc1 and Src involves Y600 phosphorylation, and Shc1binding also occurs with Y778 phosphorylation. EphB1controls neuronal cell development through mediating axon guidance. It also controls chemotaxis, proliferation, and polarity of hippocampal neuronal progenitor cells. The SH2 domain of GRB10 cannot bind EphB1 with an Y928F mutation. EphB1 has been linked with the development of gastric adenocarcinomas and ovarian undifferentiated carcinoma.
© Kinexus Bioinformatics Corporation 2017