Product Name: Tec (516-522) pY519
Product Number: PE-04ALH99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: Tec (516-522) pY519
Product Use: Services as a blocking peptide for use with the TEC-pY519 rabbit polyclonal antibody (Cat. No.: AB-PK829) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y519 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DDQ-pY-TSS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the TEC-pY519 rabbit polyclonal antibody (Cat. No.: AB-PK829) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y519 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DDQ-pY-TSS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1068.92 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tec - pY519 phosphosite-specific antibody (Cat. No.: AB-PK829)
Peptide Molecular Mass Calculated: 1068.92 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tec - pY519 phosphosite-specific antibody (Cat. No.: AB-PK829)
Scientific Background: TEC is a non-receptorprotein-tyrosine kinase of the TK group and Tec family. It is an important component of T cell signalling and T cell activation in the adaptive immune response. When T-cells or B-cells receptors are activated, this leads to the recruitment of TEC to the cell membrane, where it is phosphorylated at Y519. It regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells, and osteoclast differentiation. It phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signalling. It mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. It plays a redundant role to BTK in BCR-signalling for B-cell development and activation, via phosphorylation of STAP1. It is involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. TEC phosphorylates GRB10. TEC is involved in G protein-coupled receptor- and integrin-mediated signallings in blood platelets. It plays a role in hepatocyte proliferation and liver regeneration and in HGF-induced ERK signalling. SOCS1 is an inhibitor of TEC kinase activity. TEC is a major binder of dasatinib, which is used for BCR/ABL-positive CML treatment.
© Kinexus Bioinformatics Corporation 2017