Product Name: NUAK1 (208-214) pT211
Product Number: PE-04AKS99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 | ||
| 5 mg | 185.00 |
Peptide Name: NUAK1 (208-214) pT211
Product Use: Services as a blocking peptide for use with the NuaK1-pT211 rabbit polyclonal antibody (Cat. No.: AB-PK737) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T211 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: FLQ-pT-FCG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the NuaK1-pT211 rabbit polyclonal antibody (Cat. No.: AB-PK737) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. T211 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: FLQ-pT-FCG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1069.14 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: NUAK1 - pT211 phosphosite-specific antibody (Cat. No.: AB-PK737)
Peptide Molecular Mass Calculated: 1069.14 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: NUAK1 - pT211 phosphosite-specific antibody (Cat. No.: AB-PK737)
Scientific Background: NuaK1 is a protein-serine/threonine kinase of the CAMK group and CAMKL family. It mediates cell proliferation, tumour progression, senescence, cell ploidy levels, and cell adhesion. It is Involved in tolerance to glucose starvation. It is activated by phosphorylation at T211 and S600. A T211A NuaK1 mutation can inhibit LKB1/LKB1-mediated activation and phosphorylation of NuaK1, while ablating induction of senescence. The I400K and L401K mutations can lead to interrupted NuaK1 complex with PPP1CB, and inhibiting regulation of PP1 activity. It suppresses Fas-induced apoptosis by phosphorylation of CASP6, and suppresses the activation of the caspase and the subsequent cleavage of CFLAR. It phosphorylates ATM. Ploidy by NuaK1 is mediated through the phosphorylation of S464 of LATS1. Cell adhesion control by NuaK1 is mediated via PP1 (protein phosphatase 1). Phosphorylation via PKB/Akt1 can be prevented through the S600A mutation.
© Kinexus Bioinformatics Corporation 2017