Product Name: CaMK2a (282-289) pT286
Product Number: PE-04AJB90
| Size: | 200 µg | Price: | 40.00 | |
| 1 mg | $US | 80.00 | ||
| 5 mg | 187.00 |
Peptide Name: CaMK2a (282-289) pT286
Product Use: Services as a blocking peptide for use with the CaMK2a-pT286 rabbit polyclonal antibody (Cat. No.: AB-PK555) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the kinase catalytic domain and the CamKII-AD domains. The major site of in vivo phosphorylation of CaMK2a. T286 phosphorylation stimulates calcium/calmodulin-independent phosphotransferase activity and regulates cell growth, intracellular location, molecular association, including inducing interaction with GIT1 and MAP2, and inhibiting interaction with MBP and neurogranin.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: HRQE-pT-VDC
Product Use: Services as a blocking peptide for use with the CaMK2a-pT286 rabbit polyclonal antibody (Cat. No.: AB-PK555) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the region between the kinase catalytic domain and the CamKII-AD domains. The major site of in vivo phosphorylation of CaMK2a. T286 phosphorylation stimulates calcium/calmodulin-independent phosphotransferase activity and regulates cell growth, intracellular location, molecular association, including inducing interaction with GIT1 and MAP2, and inhibiting interaction with MBP and neurogranin.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: HRQE-pT-VDC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1137.1 Da
Peptide Purity Percent after Synthesis and Purification: 90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: CaMK2a - pT286 phosphosite-specific antibody (Cat. No.: AB-PK555)
Peptide Modifications C Terminus: Amide
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1137.1 Da
Peptide Purity Percent after Synthesis and Purification: 90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: CaMK2a - pT286 phosphosite-specific antibody (Cat. No.: AB-PK555)
Scientific Background: CaMK2a is a protein-serine/threonine kinase of the CAMK group and CAMK2 family. It is a calcium/calmodulin-activated protein kinase involved in neurotransmitter release and long term potentiation in neurons. Autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state
© Kinexus Bioinformatics Corporation 2017