Product Name: BMPR2 (372-378) pS375
Product Number: PE-04AIS99
| Size: | 200 µg | Price: | 42.00 | |
| 1 mg | $US | 84.00 |
Peptide Name: BMPR2 (372-378) pS375
Product Use: Services as a blocking peptide for use with the BMPR2-pS375 rabbit polyclonal antibody (Cat. No.: AB-PK544) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S375 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAI-pS-EVG
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the BMPR2-pS375 rabbit polyclonal antibody (Cat. No.: AB-PK544) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. S375 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAI-pS-EVG
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 898.91 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: BMPR2 - pS375 phosphosite-specific antibody (Cat. No.: AB-PK544)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 898.91 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: BMPR2 - pS375 phosphosite-specific antibody (Cat. No.: AB-PK544)
Scientific Background: BMPR2 (bone morphogenetic protein receptor type II) is a protein-serine/threonine kinase of the TKL group and STKR family. It is a transmembrane receptor kinase that is a member of the bone morphogenetic protein (BMP) receptor family. BMPR2 functions to bind BMPs, which are named for their role in endochondral bone formation and embryogenesis. Activated by binding bone morphogenetic protein. This type II receptor phosphorylates and activates type I receptors which autophosphorylate, then phosphorylate SMAD transcriptional regulators. Insertional mutagenesis studies in mice support a role for this protein kinase in mouse cancer oncogenesis.
© Kinexus Bioinformatics Corporation 2017