Product Name: Ack1 (281-287) pY284
Product Number: PE-04AIA80
| Size: | 200 µg | Price: | 35.00 | |
| 1 mg | $US | 71.00 | ||
| 5 mg | 153.00 |
Peptide Name: Ack1 (281-287) pY284
Product Use: Services as a blocking peptide for use with the ACK1-pY284 rabbit polyclonal antibody (Cat. No.: AB-PK511) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y284 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DDH-pY-VMQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the ACK1-pY284 rabbit polyclonal antibody (Cat. No.: AB-PK511) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y284 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: DDH-pY-VMQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1160.15 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Ack1 - pY284 phosphosite-specific antibody (Cat. No.: AB-PK511)
Peptide Molecular Mass Calculated: 1160.15 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Ack1 - pY284 phosphosite-specific antibody (Cat. No.: AB-PK511)
Scientific Background: Ack1 (TNK2) is a protein-tyrosine kinase of the TK group and Ack family. It appears to be a tumour suppressor protein (TSP). Cancer-related mutations in Ack1 in human tumours point to a loss of function of the protein kinase. The active form of the protein kinase normally acts to inhibit tumour cell proliferation. It is implicated in numerous roles, including: cell spreading and migration, cell survival, cell growth, and proliferation. TNK2 is known to phosphorylate: Akt1, AR, MCF2, WASL and WWOX. In this capacity TNK2 negatively regulates the tumour suppressor, WWOX, whilst activating the oncoproteins, Akt1 and AR. Mutations in this gene have been observed in ovarian, skin, and stomach tumours. Phosphorylation at Y284 in Ack1 increases its phosphotransferase activity. Its SH3 domain appears to play an autoinhibitory role.
© Kinexus Bioinformatics Corporation 2017