Product Name: Tyk2 (1051-1058) pY1054+pY1055
Product Number: PE-04AHX99
| Size: | 200 µg | Price: | 74.00 | |
| 1 mg | $US | 148.00 | ||
| 5 mg | 325.00 |
Peptide Name: Tyk2 (1051-1058) pY1054+pY1055
Product Use: Services as a blocking peptide for use with the TYK2-pY1054+pY1055 rabbit polyclonal antibody (Cat. No.: AB-PK845) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y1054 and Y1055 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHE-pY-pY-RVR
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the TYK2-pY1054+pY1055 rabbit polyclonal antibody (Cat. No.: AB-PK845) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y1054 and Y1055 phosphorylation stimulate phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: GHE-pY-pY-RVR
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1412.35 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tyk2 - pY1054+pY1055 phosphosite-specific antibody (Cat. No.: AB-PK845)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1412.35 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: Tyk2 - pY1054+pY1055 phosphosite-specific antibody (Cat. No.: AB-PK845)
Scientific Background: Tyk2 is a protein-tyrosine kinase of the TK group and JakA family. Phosphorylation of Y1054 and Y1055 increases phosphotransferase activity. Tyk2 mediates intracellular signal transduction from Type I interferon-alpha/beta receptor (IFN) signalling and phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumours.
© Kinexus Bioinformatics Corporation 2017