Product Name: PKM2 (387-393) pY390
Product Number: PE-04AHE95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: PKM2 (387-393) pY390
Product Use: Services as a blocking peptide for use with the PKM2-pY390 rabbit polyclonal antibody (Cat. No.: AB-PN529) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located at the end of the PK domain. A major phosphorylation site in PKM2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAI-pY-HLQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the PKM2-pY390 rabbit polyclonal antibody (Cat. No.: AB-PN529) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located at the end of the PK domain. A major phosphorylation site in PKM2. The effect of its phosphorylation is unclear.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAI-pY-HLQ
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1069.12 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PKM2 - pY390 phosphosite-specific antibody (Cat. No.: AB-PN529)
Peptide Molecular Mass Calculated: 1069.12 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PKM2 - pY390 phosphosite-specific antibody (Cat. No.: AB-PN529)
Scientific Background: PKM2 functions as a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, and generates ATP. It stimulates POU5F1-mediated transcriptional activation. It appears to plays a general role in caspase independent cell death of tumour cells. The ratio between its highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is thought to be important for tumour cell proliferation and survival.
© Kinexus Bioinformatics Corporation 2017