Product Name: DDR2 (733-739) pY736
Product Number: PE-04AHB95
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: DDR2 (733-739) pY736
Product Use: Services as a blocking peptide for use with the DDR2-pY736 rabbit polyclonal antibody (Cat. No.: AB-PK593) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y736 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RNL-pY-SGD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the DDR2-pY736 rabbit polyclonal antibody (Cat. No.: AB-PK593) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T-loop between subdomains VII and VIII. Y736 phosphorylation stimulates phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RNL-pY-SGD
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1078.03 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: DDR2 - pY736 phosphosite-specific antibody (Cat. No.: AB-PK593)
Peptide Molecular Mass Calculated: 1078.03 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: DDR2 - pY736 phosphosite-specific antibody (Cat. No.: AB-PK593)
Scientific Background: DDR2 is a protein-tyrosine kinase of the TK group and DDR family. It is a receptor kinase that binds fibrillar collagen and has roles in the regulation of cell differentiation, extracellular matrix remodeling, cell migration, and cell proliferation. DDR2 is necessary for normal bone development and promotes fibroblast migration and proliferation, and has a critical role in wound healing. This kinase is highly expressed and widely distributed in most tested human tissues except in the brain where it is poorly expressed. Orthologues of DDR2 are highly conserved in vertebrates and insects. Phosphorylation of DDR2 at Y471 induces interaction with Shc1, whereas phosphorylation at Y740 induces interaction with Nck2 and SHP2. DDR2 isfeatures a distinct extracellular region encompassing a factor VIII-like domain, which is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung. DDR2 has also been linked with the development of lung large cell carcinomas and spondyloepimetaphyseal dysplasia short limb-hand type (semd-sl).
© Kinexus Bioinformatics Corporation 2017