Product Name: PECAM1 (710-716) pY713
Product Number: PE-04AEZ99
| Size: | 200 µg | Price: | 47.00 | |
| 1 mg | $US | 94.00 | ||
| 5 mg | 206.00 |
Peptide Name: PECAM1 (710-716) pY713
Product Use: Services as a blocking peptide for use with the PECAM-1-pY713 rabbit polyclonal antibody (Cat. No.: AB-PN523) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminal region of the protein after the transmembrane domain. This is the major in vivo phosphorylation site in PECAM-1. Phosphorylation induces activity and interaction with SHP-2 and STAT5A.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ETV-pY-SEV
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the PECAM-1-pY713 rabbit polyclonal antibody (Cat. No.: AB-PN523) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminal region of the protein after the transmembrane domain. This is the major in vivo phosphorylation site in PECAM-1. Phosphorylation induces activity and interaction with SHP-2 and STAT5A.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: ETV-pY-SEV
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1079.05 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PECAM1 - pY713 phosphosite-specific antibody (Cat. No.: AB-PN523)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1079.05 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PECAM1 - pY713 phosphosite-specific antibody (Cat. No.: AB-PN523)
Scientific Background: PECAM1 is a cell adhesion protein that is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Phosphorylation at Y690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. It prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, to promote tethering of dying cells to phagocytes. During apoptosis, the inside-out signalling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, and triggers the process of engulfment. Isoform Delta15 is unable to protect against apoptosis. It modulates BDKRB2 activation. It regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
© Kinexus Bioinformatics Corporation 2017