Product Name: STAT3 (702-708) pY705+pT708
Product Number: PE-04ADO95
| Size: | 200 µg | Price: | 58.00 | |
| 1 mg | $US | 116.00 | ||
| 5 mg | 273.00 |
Peptide Name: STAT3 (702-708) pY705+pT708
Product Use: Services as a blocking peptide for use with the STAT3-pY705+pT708 rabbit polyclonal antibody (Cat. No.: AB-PN539) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of the transcription factor. Y705 is the major in vivo phosphorylation site in STAT3. Phosphorylation induces transcriptional activity and interaction with DNA, PKCD and STAT1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAP-pY-LK-pT
Peptide Modifications N Terminus: Free amino
Product Use: Services as a blocking peptide for use with the STAT3-pY705+pT708 rabbit polyclonal antibody (Cat. No.: AB-PN539) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the C-terminus of the transcription factor. Y705 is the major in vivo phosphorylation site in STAT3. Phosphorylation induces transcriptional activity and interaction with DNA, PKCD and STAT1.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: AAP-pY-LK-pT
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1097.06 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: STAT3 - pY705+pT708 phosphosite-specific antibody (Cat. No.: AB-PN539)
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1097.06 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: STAT3 - pY705+pT708 phosphosite-specific antibody (Cat. No.: AB-PN539)
Scientific Background: STAT3 is a Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, it recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). It mediates cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. It also binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.
© Kinexus Bioinformatics Corporation 2017