Product Name: PFN1 (126-132) pY129
Product Number: PE-04ADJ75
| Size: | 200 µg | Price: | 11.00 | |
| 1 mg | $US | 21.00 | ||
| 5 mg | 58.00 |
Peptide Name: PFN1 (126-132) pY129
Product Use: Services as a blocking peptide for use with the PFN1-pY129 rabbit polyclonal antibody (Cat. No.: AB-PN524) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the at the end of the Profilin domain. This is the major in vivo phosphorylation site in Profilin 1. Phosphorylation induces interaction with VHL.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KKC-pY-EMA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Product Use: Services as a blocking peptide for use with the PFN1-pY129 rabbit polyclonal antibody (Cat. No.: AB-PN524) that is also available from Kinexus. This phosphopeptide may also be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the at the end of the Profilin domain. This is the major in vivo phosphorylation site in Profilin 1. Phosphorylation induces interaction with VHL.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: KKC-pY-EMA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1126.24 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PFN1 - pY129 phosphosite-specific antibody (Cat. No.: AB-PN524)
Peptide Molecular Mass Calculated: 1126.24 Da
Peptide Purity Percent after Synthesis and Purification: >50
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PFN1 - pY129 phosphosite-specific antibody (Cat. No.: AB-PN524)
Scientific Background: At high concentrations, Profilin 1 binds actin and prevents its polymerization, whereas it enhances actin polymerization at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and diacylglycerol by sequestering PIP2. It inhibits androgen receptor (AR) and HTT aggregation, and the binding of G-actin that is essential for its inhibition of AR.
© Kinexus Bioinformatics Corporation 2017