Product Name: MuSK (752-759) pY756
Product Number: PE-04ABM80
| Size: | 200 µg | Price: | 38.00 | |
| 1 mg | $US | 75.00 | ||
| 5 mg | 163.00 |
Peptide Name: MuSK (752-759) pY756
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y756 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SADY-pY-KAN
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the protein kinase catalytic domain activation T loop region between subdomains VII and VIII. Y756 phosphorylation is predicted to be stimulatory for phosphotransferase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: SADY-pY-KAN
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Modifications Other: Phosphorylated
Peptide Molecular Mass Calculated: 1226.2 Da
Peptide Purity Percent after Synthesis and Purification: 80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Purity Percent after Synthesis and Purification: 80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: Human Musk is a protein-tyrosine kinase of the TK group of protein kinases in the Musk family. This kinase is moderate to highly expressed in most tested human tissues except in the bladder, brain, pericardium, pituitary, spinal cord, trachea and vagina where it is notably low. Orthologues of Musk are highly conserved in vertebrates and insects. MUSK is necessary for neuromuscular junction formation (1). Musk gene expression is highly regulated during neuromuscular junction and it is involved in intercellular communication present on the surface of cells that are activated by specific protein ligands. Musk members play a key role in growth and differentiation of those cell types. Agrin signals through Musk to cluster acetylcholine receptors on the postsynaptic membrane of the neuromuscular junction. Musk interacts with Dok7, which may regulates its phosphotransferase activity. Dok7 is essential for MUSK activation in cultured myotubes. Musk also plays a critical role in the development of normal blood vessels (2). Musk has been linked with the development of lung neuroendocrine carcinomas.
© Kinexus Bioinformatics Corporation 2017