Product Name: EpoR (365-375) pY368
Product Number: PE-04AAM95
Size: 200 µg      Price:46.00
1 mg      $US92.00
Peptide Name: EpoR (365-375) pY368

Product Use: This phosphopeptide may be useful as a substrate for screening the phosphatase activity of protein phosphatases. The peptide sequence is located in the cytoplasmic domain. Phosphorylation at this site induces interaction with SOCS3 and STAT5A.

Peptide Production Method: Solid-phase peptide synthesis

Peptide Origin: Homo sapiens

Peptide Sequence: QDT-pY-LVLDKWL

Peptide Modifications N Terminus: Acetyl

Peptide Modifications C Terminus: Amide

Peptide Modifications Other: Phosphorylated

Peptide Molecular Mass Calculated: 1514.6 Da

Peptide Purity Percent after Synthesis and Purification: >95

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Scientific Background: EpoR is the rceptor for erythropoietin. It mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signalling cascade. In some cell types, can also activate the transcription factors STAT1 and STAT3, and the protein-tyrosine kinase Lyn.
References

[1] Müller J, Sperl B, Reindl W, Kiessling A, Berg T (2008) Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5. ChemBioChem 9(5): 723–727

[2] Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN (1996) Mol. Cell. Biol.16, 1622–1631.