Product Name: SRPKSubtide
Product Number: PE-01BJL95
Size: 200 µg      Price:37.00
1 mg      $US74.00
5 mg      174.00
Peptide Name: SRPKSubtide

Product Use: For assaying the phosphotransferase activity of Serine/arginine-rich protein-specific kinase 1; SRPK1a protein kinase (UniProt ID Q96SB4).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: RFRRKSFRRRG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1695.04 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid
Storage Conditions: -20°C

Peptide Recommended Enzyme: SRPK

Scientific Background: SRPK1 (SFRSK1) is one of several protein kinases that can phosphorylate KinSub5RRLSP. It is a protein-serine/threonine kinase of the CMGC group and SRPK family. This kinase is moderate to highly expressed in most tested human tissues except apparently in the brain and spinal cord. SRPK1 is activated by phosphorylation at S51 and S555. In human cancer cells, it was observed that inactivation of SRPK1 induces cellular resistance to anticancer drugs such as cisplatin and bleomycin. SRPK1 phosphorylates serine/arginine-rich (SR) proteins, such as splicing factors ASF/SF2, SC35, and SRp55, in their arginine/serine-rich (RS) domains in vitro. Consequently, it is believed that SRPK1 plays a key role in regulation of both constitutive and alternative splicing by regulating intracellular localization of splicing factors.