Product Name: PKCE/ZSubtide
Product Number: PE-01BIT95
Size: 200 µg      Price:40.00
1 mg      $US80.00
5 mg      187.00
Peptide Name: PKCE/ZSubtide

Product Use: For assaying the phosphotransferase activity of Protein kinase C epsilon type (UniProt ID Q02156).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: RLKRRKSFRRRG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1789.19 Da

Peptide Purity Percent after Synthesis and Purification: >90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Peptide Recommended Enzyme: PKCE/Z

Scientific Background: PKCe (PRKCE, PPK-epsilon) is a member of the AGC group of protein-serine/threonine kinases in the PKC family, and Eta subfamily. This kinase is moderate to highly expressed in most tested human tissues except in the brain and spinal cord where it is poorly expressed. PKCe is activated by phosphorylation at T566, T710 and S729. Phosphorylation of S729 also promotes dephosphorylation of T566 and possibly nuclear import. Phosphorylation at S368 induces interaction with 14-3-3 beta. PKCe is involved in many different cellular functions, such as neuron channel activation, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice indicate that this kinase is important for lipopolysaccharide (LPS)-mediated signalling in activated macrophages and may control anxiety-like behavior. PKCe has been linked with the development of Alzheimer's disease, colorectal adenocarcinoma, prostate and thyroid cancers.