Product Name: MAPKAPK2Subtide
Product Number: PE-01BHZ85
Size: 200 µg      Price:39.00
1 mg      $US78.00
5 mg      168.00
Peptide Name: MAPKAPK2Subtide

Product Use: For assaying the phosphotransferase activity of Mitogen-activated protein kinase-activated protein kinase 2 (UniProt ID P49137).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: RFLLRRLSFRVFLA

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1968.45 Da

Peptide Purity Percent after Synthesis and Purification: >80

Peptide Appearance: White powder

Peptide Form: Solid
Storage Conditions: -20°C

Peptide Recommended Enzyme: MAPKAPK2

Scientific Background: MAPKAPK2 is a protein-serine/threonine kinase that is a member of the CAMK group of protein kinases in the MAPKAPK family, and MAPKAPK subfamily. This kinase is highly expressed and widely distributed in most tested human tissues. It functions in the regulation of various cellular processes, including cytokine production, endocytosis, cytoskeletal reorganization, cell migration, cell cycle control, chromatin remodelling, response to DNA damage, and transcription. Phosphorylation of T222, T334 and S272 increases its phosphotransferase activity. It seems to be activated by two distinct pathways: the first involves the stimulation of p42/p44 MAPK by growth factors, the second, triggered by stress and heat shock, depends on the activation of MPK2 and upstream MAPKK/MAPKKK. It mediates both ERK and p38 MAPK-dependent neutrophil responses, participates in TNFa-stimulated exocytosis of secretory vesicles in neutrophils, and plays a role in phagocytosis-induced respiratory burst activity. Another one of its major substrates is HSP27, a protein responsble for stimulating actin polymerization in order to facilitate the recovery from cytoskeleton destruction during cellular stress. Over-expression of the MAPKAPK2 gene has been linked to Multiple Myeloma resistance to chemotherapy, and it has been found to play a role in neuroinflammatory and neurodegenerative diseases such as Alzheimer's. MAPKAPK2 may be a tumour requiring protein (TRP). It has also been implicated in the promotion of cancer development and tumourigenesis, specifically lung cancer.