Product Name: DDR2Subtide
Product Number: PE-01BHB90
Size: 1 mg      Price:85.00
5 mg      $US201.00
20 mg      316.00
Peptide Name: DDR2Subtide

Product Use: For assaying the phosphotransferase activity of Discoidin domain-containing receptor 2 (UniProt ID Q16832).

Peptide Production Method: Solid-phase peptide synthesis

Peptide Sequence: KKGGEDPDYFYVG

Peptide Modifications N Terminus: Free amino

Peptide Modifications C Terminus: βAla-Cys

Peptide Molecular Mass Calculated: 1648.75 Da

Peptide Purity Percent after Synthesis and Purification: ~90

Peptide Appearance: White powder

Peptide Form: Solid

Storage Conditions: -20°C

Peptide Recommended Enzyme: DDR2

Scientific Background: DDR2 is a protein-tyrosine kinase of the TK group and DDR family. It is a receptor kinase that binds fibrillar collagen and has roles in the regulation of cell differentiation, extracellular matrix remodeling, cell migration, and cell proliferation. DDR2 is necessary for normal bone development and promotes fibroblast migration and proliferation, and has a critical role in wound healing. This kinase is highly expressed and widely distributed in most tested human tissues except in the brain where it is poorly expressed. Orthologues of DDR2 are highly conserved in vertebrates and insects. Phosphorylation of DDR2 at Y471 induces interaction with Shc1, whereas phosphorylation at Y740 induces interaction with Nck2 and SHP2. DDR2 isfeatures a distinct extracellular region encompassing a factor VIII-like domain, which is thought to be involved in the regulation of cell growth, differentiation, and metabolism. DDR2 plays a role in the regulation of collagen turnover mediated by smooth muscle cells in obstructive diseases of blood vessels and the lung. DDR2 has also been linked with the development of lung large cell carcinomas and spondyloepimetaphyseal dysplasia short limb-hand type (semd-sl).