Product Name: DAPKSubtide
Product Number: PE-01BGZ95
Size: | 200 µg | | Price: | 42.00 |
| 1 mg | | $US | 84.00 |
| 5 mg | | | 185.00 |
Peptide Name: DAPKSubtide
Product Use: For assaying the phosphotransferase activity of Death-associated protein kinase 3 (UniProt ID O43293).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KRKRAKTFRVA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1534.87 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: DAPK
Scientific Background: DAPK3 (also known as ZIP) is a protein-serine/threonine kinase that is a member of the CAMK group of protein kinases in the DAPK family. This kinase is moderate to highly expressed in most tested human tissues. Orthologues of DAPK3 are highly conserved in animals and plants. DAPK3 is activated by phosphorylation at T180, T225, and T265. Homodimers of DAPK3 or heterodimers with ATF4 formed via a leucine zipper domain is required for full enzymatic activity. DAPK3 plays a role in apoptosis. It phosphorylates core histones H3 and H4, and myosin light chain in vitro. DAPK3 interacts with transcription and splicing factors as well as with pro-apoptotic protein Par-4.