Product Name: CLKSubtide
Product Number: PE-01BGX80
| Size: | 200 µg | Price: | 39.00 | |
| 1 mg | $US | 78.00 | ||
| 5 mg | 168.00 |
Peptide Name: CLKSubtide
Product Use: For assaying the phosphotransferase activity of Dual specificity protein kinase CLK2 (UniProt ID P49760).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: RSRSRSRSRSRSRB
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1864.3 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: For assaying the phosphotransferase activity of Dual specificity protein kinase CLK2 (UniProt ID P49760).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: RSRSRSRSRSRSRB
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1864.3 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: CLK
Peptide Recommended Enzyme: CLK
Scientific Background: CLK2 is a member of the CMGC group of protein kinases in the CLK family. This kinase is highly expressed and widely distributed in most tested human tissues. Orthologues of CLK2 are amongst the most highly conserved protein kinases in animals, plants, fungi and unicellular eukaryotes. CLK2 has been shown to phosphorylate SR proteins and to influence alternative splicing in overexpression systems. CLK family mmbers activate PTP-1B family members, and this phosphatase may be an important cellular target for CLK action. Mutations in the CLK2 proteins affect organismal features such as development, behavior, reproduction, and aging as well as cellular features such as the cell cycle, apoptosis, the DNA replication checkpoint, and telomere length.
© Kinexus Bioinformatics Corporation 2017