Product Name: CDK5Selectide
Product Number: PE-01BGQ95
| Size: | 200 µg | Price: | 29.00 | |
| 1 mg | $US | 57.00 | ||
| 5 mg | 135.00 |
Peptide Name: CDK5Selectide
Product Use: For assaying the phosphotransferase activity of Cyclin-dependent protein-serine kinase 5 (UniProt ID Q00535).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KTPRRRRA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1214.5 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: For assaying the phosphotransferase activity of Cyclin-dependent protein-serine kinase 5 (UniProt ID Q00535).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KTPRRRRA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1214.5 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: CDK5
Peptide Recommended Enzyme: CDK5
Scientific Background: CDK5 is a protein-serine/threonine kinase of the CMGC group and CDK family. It is required for cell cycle arrest in neuronal cells. It is activated by binding p35 protein. Phosphorylation at S159 increases phosphotransferase activity. Phosphorylation at T14 and Y15 inhibits phosphotransferase activity. CDK5 has been observed to be proline-directed and to phosphorylate SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. CDK5 has been implicated in Aneurysmal bone cyst, which is a bone cancer that will affect bone, endothelial tissue, and bone marrow.
© Kinexus Bioinformatics Corporation 2017