Product Name: AckSubtide
Product Number: PE-01BGE95
| Size: | 1 mg | Price: | 97.00 | |
| 5 mg | $US | 213.00 | ||
| 20 mg | 389.00 |
Peptide Name: AckSubtide
Product Use: For assaying the phosphotransferase activity of activated CDC42 kinase 1 (UniProt ID Q07912).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEDDDYVNPGA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1581.8 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Product Use: For assaying the phosphotransferase activity of activated CDC42 kinase 1 (UniProt ID Q07912).
Peptide Production Method: Solid-phase peptide synthesis
Peptide Sequence: KKGEDDDYVNPGA
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 1581.8 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Recommended Enzyme: Ack
Peptide Recommended Enzyme: Ack
Scientific Background: Ack1 (TNK2) is a protein-tyrosine kinase of the TK group and Ack family. It appears to be a tumour suppressor protein (TSP). Cancer-related mutations in Ack1 in human tumours point to a loss of function of the protein kinase. The active form of the protein kinase normally acts to inhibit tumour cell proliferation. It is implicated in numerous roles, including: cell spreading and migration, cell survival, cell growth, and proliferation. TNK2 is known to phosphorylate: Akt1, AR, MCF2, WASL and WWOX. In this capacity TNK2 negatively regulates the tumour suppressor, WWOX, whilst activating the oncoproteins, Akt1 and AR. Mutations in this gene have been observed in ovarian, skin, and stomach tumours. Phosphorylation at Y284 in Ack1 increases its phosphotransferase activity. Its SH3 domain appears to play an autoinhibitory role.
© Kinexus Bioinformatics Corporation 2017