Product Name: H-Ras (58-64)
Product Number: PE-01BFZ90
| Size: | 200 µg | Price: | 26.00 | |
| 1 mg | $US | 52.00 | ||
| 5 mg | 129.00 |
Peptide Name: H-Ras (58-64)
Product Use: The peptide sequence is located in the GTP-binding site. Q61R is an oncogenic mutation in H-Ras and other Ras isoforms that leads to constitutive activation due to inhibition of its GTPase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: TAGREEY
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 998.0 Da
Peptide Purity Percent after Synthesis and Purification: 90
Product Use: The peptide sequence is located in the GTP-binding site. Q61R is an oncogenic mutation in H-Ras and other Ras isoforms that leads to constitutive activation due to inhibition of its GTPase activity.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: TAGREEY
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: βAla-Cys
Peptide Molecular Mass Calculated: 998.0 Da
Peptide Purity Percent after Synthesis and Purification: 90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Peptide Form: Solid
Storage Conditions: -20°C
Scientific Background: H-Ras is a small monomeric G protein that binds GDP/GTP and possess intrinsic GTPase activity. It alternates between an inactive form bound to GDP and an active form bound to GTP. It is normally activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs). Mutations that compromise the GTPase activity of H-Ras (e.g. at G12) produce constitutively active, oncogenic forms of the protein, which commonly arise in human cancers.
© Kinexus Bioinformatics Corporation 2017