Product Name: SRPK2 (343-361)
Product Number: PE-01BFI85T
| Size: | 1 mg | Price: | 14.00 | |
| 5 mg | $US | 29.00 | ||
| 20 mg | 66.00 |
Peptide Name: SRPK2 (343-361)
Product Use: Services as a blocking peptide for use with the SRPK2-IKCD rabbit polyclonal antibody (Cat. No.: AB-NK296-1) that is also available from Kinexus. The peptide sequence is located in the insert into kinase domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGEAEDQEEKEDAEKENIEK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2322.3 Da
Peptide Purity Percent after Synthesis and Purification: >80
Product Use: Services as a blocking peptide for use with the SRPK2-IKCD rabbit polyclonal antibody (Cat. No.: AB-NK296-1) that is also available from Kinexus. The peptide sequence is located in the insert into kinase domain.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGEAEDQEEKEDAEKENIEK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2322.3 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK2 pan-specific antibody (Cat. No.: AB-NK296-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: SRPK2 pan-specific antibody (Cat. No.: AB-NK296-1)
Scientific Background: SRPK2 (SFRSK2) is a protein-serine/threonine kinase of the CMGC group and SRPK family. This kinase is moderate to highly expressed in most tested human tissues. It is a member of the serine/arginine (SR) protein-specific kinase family that are cell cycle-regulated protein kinases which phosphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing events. It phosphorylates SFRS1 and SFRS2 on serine residues. It is involved in spliceosome assembly and splicing factor trafficking. SRPK2 is activated by phosphorylation at S52 and S588. SRPK2 knock down results in hypophosphorylation of the serine/arginine domain-containing human PRP28 protein thereby destabilizing PRP28 association with the tri-snRNP. RNAi-mediated depletion in HeLa cells showed that SRPK2 is essential for cell viability, and it is required for spliceosomal B complex formation. SRPK2 has been linked with the development of glioblastoma multiforme (GM).
© Kinexus Bioinformatics Corporation 2017