Product Name: PAK6 (73-91)
Product Number: PE-01BEH90
| Size: | 200 µg | Price: | 56.00 | |
| 1 mg | $US | 112.00 | ||
| 5 mg | 264.00 |
Peptide Name: PAK6 (73-91)
Product Use: Services as a blocking peptide for use with the PAK6-APBD rabbit polyclonal antibody (Cat. No.: AB-NK124-2) that is also available from Kinexus. The peptide sequence is located in the post-PBD.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGSAMPVDGYISGLLNDIQK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2080.4 Da
Peptide Purity Percent after Synthesis and Purification: >90
Product Use: Services as a blocking peptide for use with the PAK6-APBD rabbit polyclonal antibody (Cat. No.: AB-NK124-2) that is also available from Kinexus. The peptide sequence is located in the post-PBD.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGSAMPVDGYISGLLNDIQK
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2080.4 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PAK6 pan-specific antibody (Cat. No.: AB-NK124-2)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: PAK6 pan-specific antibody (Cat. No.: AB-NK124-2)
Scientific Background: PAK6 (PAK5) is a protein-serine/threonine kinase of the STE group and STE20 family. It can regulate gene transcription. MAPKK6/MAP2K6 or AR can induce PAK6 activity which will induce phosphorylation of the DNA-binding domain on an androgen receptor (AR) protein. The activation of PAK6 through MAP2K6/MAPKK6 can be inhibited through the three mutations S165A, S560A, and Y566F. It plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. It phosphorylates the DNA-binding domain of androgen receptor/AR and inhibits AR-mediated transcription. It also inhibits ESR1-mediated transcription. It may play a role in cytoskeleton regulation by interacting with IQGAP1. It can protect cells from apoptosis through phosphorylation of BAD. PAK6 suppresses tumour progression through regulation of androgen receptor homeostasis.
© Kinexus Bioinformatics Corporation 2017