Product Name: MLK1 (1086-1104)
Product Number: PE-01BDY01
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Peptide Name: MLK1 (1086-1104)
Product Use: Services as a blocking peptide for use with the MLK1-CT rabbit polyclonal antibody (Cat. No.: AB-NK278-1) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAELNTHRPAPYEIQQEFWS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 2418.6 Da
Peptide Purity Percent after Synthesis and Purification: 30
Product Use: Services as a blocking peptide for use with the MLK1-CT rabbit polyclonal antibody (Cat. No.: AB-NK278-1) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CAELNTHRPAPYEIQQEFWS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 2418.6 Da
Peptide Purity Percent after Synthesis and Purification: 30
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MLK1 pan-specific antibody (Cat. No.: AB-NK278-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: MLK1 pan-specific antibody (Cat. No.: AB-NK278-1)
Scientific Background: MLK1 (MAP3K9) is a protein-serine/threonine kinase of the TKL group and MLK family. It links to MAP kinases and will mediate activation of MKK/JNK via MAP2K4/MKK4 and MAP2K7/MKK7. Phosphorylation of T304, S308 and T312 increases MLK1's phosphotransferase activity. A mild effect on threonine phosphorylation and a minor impairment of JNK signalling can occur with a T305A mutation. Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. The MKK/JNK pathway is involved in mediating release of cytochrome c from the mitochondria and inducing cell death via apoptosis. The MKK/JNK signalling pathway regulates stress response via activator protein-1 (Jun) and GATA4 transcription factors. It also plays a role in mitochondrial death signalling pathway, including the release cytochrome c, leading to cell death via apoptosis. MLK1 may be an oncoprotein (OP). In non-small-cell lung cancers, a gain of function has been observed with MLK1 (MAP3K9), which results in downstream activation of ERK1 and ERK2 MAP kinases.
© Kinexus Bioinformatics Corporation 2017