Product Name: IRR (1269-1288)
Product Number: PE-01BDJ85
| Size: | 1 mg | Price: | 96.00 | |
| 5 mg | $US | 208.00 | ||
| 20 mg | 368.00 |
Peptide Name: IRR (1269-1288)
Product Use: Services as a blocking peptide for use with the IRR-BCT rabbit polyclonal antibody (Cat. No.: AB-NK273-1) that is also available from Kinexus. The peptide sequence is located in the pre-C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RGSLPTTDAEPDSSPTPRDC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2101.2 Da
Peptide Purity Percent after Synthesis and Purification: >80
Product Use: Services as a blocking peptide for use with the IRR-BCT rabbit polyclonal antibody (Cat. No.: AB-NK273-1) that is also available from Kinexus. The peptide sequence is located in the pre-C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: RGSLPTTDAEPDSSPTPRDC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2101.2 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: IRR pan-specific antibody (Cat. No.: AB-NK273-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: IRR pan-specific antibody (Cat. No.: AB-NK273-1)
Scientific Background: IRR is a receptor protein-tyrosine kinase that is a member of the TK group of protein kinases in the InsR family. IRR is required for the appearance of male gonads and for male sexual differentiation. It can sense pH in the extracellular environment. When IRR is activated a signalling cascade is started which involves IRS1 and PKB/Akt1. A mutation that can inhibit IRR autophosphorylation is Y1145F with Y1146F. Expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumorigenesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumour cell lines. IRR has also been linked with the development of glioblastoma multiforme and lung adenocarcinomas.
© Kinexus Bioinformatics Corporation 2017