Product Name: Fgr (6-25)
Product Number: PE-01BCW90
Size: | 1 mg | | Price: | 112.00 |
| 5 mg | | $US | 264.00 |
| 20 mg | | | 416.00 |
Peptide Name: Fgr (6-25)
Product Use: Services as a blocking peptide for use with the Fgr-ANT rabbit polyclonal antibody (Cat. No.: AB-NK268-1) that is also available from Kinexus. The peptide sequence is located in the post-N-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CKKLEPVATAKEDAGLEGDF
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2120.3 Da
Peptide Purity Percent after Synthesis and Purification: 90
Scientific Background: Fgr is a protein-tyrosine kinase of the TK group and Src family. It is a non-receptor kinase that transmits signals from cell surface receptors and regulates immune responses. In addition, it functions as positive regulator of cell migration and regulates cytoskeleton reorganization. Fgr appears to be an oncoprotein (OP). A Y523F mutation in Fgr is associated with strongly increased catalytic activity, which can be oncogenic and promote abnormal cell proliferation. Fgr oncogene mRNA was found to be induced in B lymphocytes by Epstein-Barr virus infection.