Product Name: DMPK2 (1-19)
Product Number: PE-01BCS80
| Size: | 200 µg | Price: | 46.00 | |
| 1 mg | $US | 91.00 | ||
| 5 mg | 198.00 |
Peptide Name: DMPK2 (1-19)
Product Use: Services as a blocking peptide for use with the DMPK2-NT rabbit polyclonal antibody (Cat. No.: AB-NK265-1) that is also available from Kinexus. The peptide sequence is located in the N-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MERRLRALEQLARGEAGGC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2115.4 Da
Peptide Purity Percent after Synthesis and Purification: >80
Product Use: Services as a blocking peptide for use with the DMPK2-NT rabbit polyclonal antibody (Cat. No.: AB-NK265-1) that is also available from Kinexus. The peptide sequence is located in the N-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: MERRLRALEQLARGEAGGC
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Amide
Peptide Molecular Mass Calculated: 2115.4 Da
Peptide Purity Percent after Synthesis and Purification: >80
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: DMPK2 pan-specific antibody (Cat. No.: AB-NK265-1)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: DMPK2 pan-specific antibody (Cat. No.: AB-NK265-1)
Scientific Background: DMPK2 is a protein-serine/threonine kinase of the AGC group and DMPK family. It is a protein kinase that is hypothesized to function as a downstream effector of CDC42 during cytoskeletal rearrangement. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation. It is maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. DMPK2 also plays a role in the regulation of actin-myosin contractility through the modulation of MYPT1 and MLC2 activity, which are required for cell invasion and motility. In addition, mutations in the DMPK2 gene have been associated with myotonic dystrophy. The DMPK2 protein is highly expressed in heart and skeletal muscle, with little to no expression in the brain, placenta, lung, liver, kidney, and pancreas. The DMPK2 gene maps to chromosome 11q13.
© Kinexus Bioinformatics Corporation 2017