Product Name: WNK4 (1229-1243)
Product Number: PE-01AZJ99
| Size: | 200 µg | Price: | 51.00 | |
| 1 mg | $US | 102.00 | ||
| 5 mg | 224.00 |
Peptide Name: WNK4 (1229-1243)
Product Use: Services as a blocking peptide for use with the WNK4-3 rabbit polyclonal antibody (Cat. No.: AB-NK255-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CRASKGVTFAGDVGRM
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1654.9 Da
Peptide Purity Percent after Synthesis and Purification: >95
Product Use: Services as a blocking peptide for use with the WNK4-3 rabbit polyclonal antibody (Cat. No.: AB-NK255-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CRASKGVTFAGDVGRM
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1654.9 Da
Peptide Purity Percent after Synthesis and Purification: >95
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: WNK4 pan-specific antibody (Cat. No.: AB-NK255-3)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: WNK4 pan-specific antibody (Cat. No.: AB-NK255-3)
Scientific Background: Wnk4 (PRKWNK4) is a protein-serine/threonine kinase of the Other group and Wnk family. It regulates electrolyte homeostasis. Wnk4 can activate the genes SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. The renal potassium channel KCNJ1, through a kinase-mediated mechanism, will be inhibited via clathrin-mediated receptor endocytosis. Wnk4 can also phosphorylate NEDD4L. Activation of Wnk4 requires autophosphorylation of S335. Phosphorylation of S331 also promotes increased activity.
© Kinexus Bioinformatics Corporation 2017