Product Name: WNK2 (2283-2297)
Product Number: PE-01AZD90
| Size: | 200 µg | Price: | 45.00 | |
| 1 mg | $US | 90.00 | ||
| 5 mg | 211.00 |
Peptide Name: WNK2 (2283-2297)
Product Use: Services as a blocking peptide for use with the WNK2-3 rabbit polyclonal antibody (Cat. No.: AB-NK253-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGSKTASFAASDPVRS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1583.6 Da
Peptide Purity Percent after Synthesis and Purification: >90
Product Use: Services as a blocking peptide for use with the WNK2-3 rabbit polyclonal antibody (Cat. No.: AB-NK253-3) that is also available from Kinexus. The peptide sequence is located in the C-terminus.
Peptide Production Method: Solid-phase peptide synthesis
Peptide Origin: Homo sapiens
Peptide Sequence: CGSKTASFAASDPVRS
Peptide Modifications N Terminus: Free amino
Peptide Modifications C Terminus: Free carboxyl
Peptide Molecular Mass Calculated: 1583.6 Da
Peptide Purity Percent after Synthesis and Purification: >90
Peptide Appearance: White powder
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: WNK2 pan-specific antibody (Cat. No.: AB-NK253-3)
Peptide Form: Solid
Storage Conditions: -20°C
Related Product 1: WNK2 pan-specific antibody (Cat. No.: AB-NK253-3)
Scientific Background: Wnk2 (PRKWNK2) is a protein-serine/threonine kinase of the Other group and Wnk family. It plays a critical role in the regulation of electrolyte homeostasis, signalling survival, and proliferation. Activation requires autophosphorylation of S356. Phosphorylation of S352 also promotes increased phosphotransferase activity. It activates sodiu-coupled chloride cotransporters and inhibits potassium-coupled chloride cotransporters. It is also involved in reducing ERK1/2 activation. ERK1/2 expression can also increase through activation of of MEK1 via Rac1-mediate PAK1 activation. WNK2 may be a tumour suppressor protein (TSP). Wnk2 is also called serologically defined colon cancer antigen 43. Loss of Wnk2 expression was found in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Loss of expression of Wnk2 is also found in meningioma and facilitates increased cell cycle progression and proliferation.
© Kinexus Bioinformatics Corporation 2017